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NO was measured using a nitrate/nitrite assay kit (Cayman Chemical) according to the manufacturer's instructions. Results were normalized to 106 cells. Data are from triplicate wells.
Erectile dysfunction is increasingly being recognized as a common, treatable disorder. The development of sildenafil has prompted an unprecedented number of men to seek treatment. Sildenafil may not be appropriate for all patients, but other therapeutic options discussed in this article may be of benefit. A thoughtful evaluation may reveal treatable causes and provide family physicians with an opportunity to become involved in the comprehensive health care of men who otherwise would not have sought medical attention.
How often do you feel stressed?
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In 2000 and 2004, the men were asked to rate their erections on a five point scale from very poor to very good. In 2002, the men answered questions related to restless legs syndrome symptoms. None of these men had diabetes or arthritis, which can both increase the risk of restless legs.
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Urinalysis: Analysis of urine can provide a wealth of information, including information on protein, sugar, and testosterone levels. Abnormal measurements of these substances can indicate diabetes, kidney disease, or a testosterone deficiency, all of which can cause ED.
Interventions Patients were randomized to receive sildenafil (n=136) or placebo (n=132) as needed, but not more than once daily, for 12 weeks. Patients took the study drug or placebo 1 hour before anticipated sexual activity. The starting dose of sildenafil citrate was 50 mg, with the option to adjust the dose to 100 mg or 25 mg based on efficacy and tolerability, to be taken as needed.
If you have high blood pressure, breast or uterine cancer, a blood-clotting disorder, diabetes, allergies, a liver disease, or a history of heart attack or stroke, you shouldn't use the birth control patch.
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If an underlying medical condition has been diagnosed, treatment of that disease is appropriate; however, therapy for chronic diseases such as diabetes, hypertension and atherosclerosis does not guarantee the return of erectile function. Any evidence of hypogonadism, hypothyroidism or other endocrine causes should be thoroughly investigated and treated. As a risk factor for atherosclerosis and a common underlying cofactor, smoking should be avoided. If the patient smokes, methods of smoking cessation should be explored. Consideration should be given to changing prescription drugs that could be contributing to the problem (Table 2).
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